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Retatrutide and cagrilintide Are synthetic peptides and investigational new drugs in multiple clinical research trials for the treatment and management of obesity and T2D

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However, higher doses of liraglutide and Ex-4 were necessary in rats with subdiaphragmatic vagal deafferentation suggesting that vagal afferent neurons contribute to the suppression of food intake induced by peripherally administered GLP-1R mimetics but other brain regions are also involved in mediating this action (Kanoski et al., 2011)